Sonkodi S
First Department of Medicine, Albert Szent-Györgyi Medical University, Szeged, Hungary.
Am J Nephrol. 1999;19(2):320-2. doi: 10.1159/000013468.
Around the turn of the 19th century, the Hungarian physiologist and clinician, Sándor Korányi, started to use physicochemical methods to estimate renal function. In parallel with the deterioration of renal function, he found characteristic changes in the freezing point depression of urine, which he termed hyposthenuria. On the basis of these findings, he was the first to introduce the functional concept of renal insufficiency.
在19世纪之交，匈牙利生理学家兼临床医生桑多尔·科拉尼开始使用物理化学方法来评估肾功能。随着肾功能的恶化，他发现尿液冰点降低存在特征性变化，他将其称为低渗尿。基于这些发现，他率先引入了肾功能不全的功能概念。
