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[重离子粒子照射治疗肺癌所致肺功能损伤的定量分析]

[Quantitative analysis of pulmonary functional damage due to heavy ion particle irradiation therapy for lung cancer].

作者信息

Homma T, Ohtsu I, Tomioka S, Inoue M, Hasegawa S, Miyamoto T

机构信息

Division of Respiratory Disease, University of Tsukuba, Ibaraki, Japan.

出版信息

Nihon Kokyuki Gakkai Zasshi. 1999 Feb;37(2):97-101.

Abstract

Seventeen patients with clinical stage I lung cancer were given irradiation therapy with heavy ion radioactive rays at 73.1 +/- 11.2 GyE. Lung injury due to irradiation was evaluated by measuring routing parameters of pulmonary function. No statistically significant changes in these parameters were observed after irradiation, even in patients followed up for a period of 1 year. Chest X-ray examinations, including CT scan images, disclosed the development of nonsegmental consolidations in the irradiated areas, changing into minor fibrosis 1 year later. We concluded that heavy ion particle irradiation has minimal impact on pulmonary function, and is of therapeutic valve to elderly patients and patients with complications.

摘要

17例临床I期肺癌患者接受了重离子放射治疗,剂量为73.1±11.2戈瑞当量(GyE)。通过测量肺功能的常规参数评估放疗引起的肺损伤。即使在随访1年的患者中,放疗后这些参数也未观察到统计学上的显著变化。胸部X线检查,包括CT扫描图像,显示照射区域出现非节段性实变,1年后转变为轻度纤维化。我们得出结论,重离子粒子照射对肺功能影响极小,对老年患者和有并发症的患者具有治疗价值。

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