Lalchev S, Tsoneva M
Eksp Med Morfol. 1976;15(3):121-7.
The authors carried out experiment on 38 Syrian hamsters, treated with cyneb, tetracycline and chlorpromasine in groups for a period of tree days. They examined the changes in the cariotypes of the animals as well as the changes in the mytotic activity of bone-marrow cells. Data were based on the analysis of 3045 metaphasic plates and 190,000 cells. It was established that the examined substances possessed mutagenic effect on the Syrian hamster in doses applied in vivo. This effect was mostly manifected in the animals treated with cyneb, followed by chlorpromasine and tetracycline. The same chemical substances reduced the mytotic activity of the bone-marrow cells. The data of the experiments in vivo correlated positively with the results of the experiments in vitro of human lymphocytic cultures, treated with the indicated substances.
作者对38只叙利亚仓鼠进行了实验，将它们分成几组，分别用克菌丹、四环素和氯丙嗪处理三天。他们检查了动物染色体核型的变化以及骨髓细胞有丝分裂活性的变化。数据基于对3045个中期板和190000个细胞的分析。结果表明，在所应用的体内剂量下，所检测的物质对叙利亚仓鼠具有诱变作用。这种作用在使用克菌丹处理的动物中最为明显，其次是氯丙嗪和四环素。相同的化学物质降低了骨髓细胞的有丝分裂活性。体内实验的数据与用上述物质处理的人淋巴细胞培养物的体外实验结果呈正相关。
