Petr T, Bárta I, Adámková M, Hrabal P, Bártová J
Institute of Hygiene and Epidemiology, Department of Nutrition Hygiene, Prague, Czechoslovakia.
Neoplasma. 1991;38(1):77-83.
The influence of partial hepatectomy on the genotoxic effect of aflatoxin B1 (AFB1) mycotoxin in male Chinese hamsters (Cricetulus griseus) was studied after application of a single i.p. dose of 1.0 mg AFB1/kg. Changes in the fractions of proliferating bone marrow cells, values of the mitotic index of liver cells and morphologic changes in liver tissue were also monitored. Partial hepatectomy reduced significantly the mutagenic activity of AFB1 measured by the frequency of chromosome aberrations in bone marrow cells during 5 days. In hepatectomized animals AFB1 cytotoxicity was significantly reduced as evaluated by changes in the values of proliferating bone marrow cell fractions. There were no important morphologic changes in the liver. In hepatectomized AFB1 treated animals mitotic activity in liver tissue was substantially lower than in hepatectomized but AFB1 untreated animals.
在给雄性中国仓鼠（黑线仓鼠）腹腔注射单次剂量为1.0毫克/千克的黄曲霉毒素B1（AFB1）后，研究了部分肝切除对AFB1霉菌毒素遗传毒性作用的影响。还监测了增殖骨髓细胞比例的变化、肝细胞有丝分裂指数的值以及肝组织的形态学变化。部分肝切除显著降低了通过骨髓细胞染色体畸变频率测量的AFB1的诱变活性，持续5天。通过增殖骨髓细胞比例值的变化评估，在肝切除动物中AFB1的细胞毒性显著降低。肝脏没有重要的形态学变化。在接受AFB1治疗的肝切除动物中，肝组织的有丝分裂活性明显低于未接受AFB1治疗的肝切除动物。
