Petkova I, Kolarova R, Popova N
Eksp Med Morfol. 1976;15(3):156-60.
The study was carried out on rats of the Wistar strain with experiments hypertension by the method of Selye, modified by Kolarova. These authors examined the activity of the enzymes of protein metabolism (GOT, GPT, AP), of glycolysis (ALD, LDH, alpha-HBDH) and of the citric cycle (MDH) in the left and right kidney at various intervals after modeling the process (3th, 15th, 30th and 90th day). The activity of the enzymes of the glycolytic chain and the cycle of Krebs in the left kidney was lowered at all stages of the experiment. Transaminase activity diminished progressively. Such a dynamics revealed the activity of adenosine phosphate as well. The activity of all examined enzymes of the right kidney showed phase changes-after initial elevation on the third day there was a lowering at the later stages of the experiment. The altered activity off the left kidney was connected with the disturbed vascularization with subsequent metabolic changes. The changes in the enzymic activity in the right kidney were assumed as a consequence of the occurred adaptive hyperfunction.
该研究以Wistar品系大鼠为实验对象，采用经科拉罗娃改良的塞利方法诱发实验性高血压。这些作者在建模过程后的不同时间间隔（第3天、第15天、第30天和第90天），检测了左右肾中蛋白质代谢酶（谷草转氨酶、谷丙转氨酶、碱性磷酸酶）、糖酵解酶（醛缩酶、乳酸脱氢酶、α-羟丁酸脱氢酶）和柠檬酸循环酶（苹果酸脱氢酶）的活性。在实验的各个阶段，左肾中糖酵解链和三羧酸循环的酶活性均降低。转氨酶活性逐渐降低。这种动态变化也显示了磷酸腺苷的活性。右肾中所有检测酶的活性均呈现阶段性变化——在第三天最初升高后，在实验后期出现降低。左肾酶活性的改变与血管化紊乱及随后的代谢变化有关。右肾酶活性的变化被认为是适应性功能亢进发生的结果。
