Zherev S, Popova N
Eksp Med Morfol. 1978;17(4):187-90.
The authors examined the activity of GOT, GPT, LDH and ALD in the myometrium of ovariectomized female rats, treated with testosterone. There was a eduction in the activity of the examined enzymes in both experimental groups of animals in comparison with the group of healthy rats. The reduction of the enzymic myometrial activity was considerably more manifested in the group of ovariectomized rats than in those treated with testosterone. The results were interpreted as a consequence of the reduced synthesis of proteins enzymes due to insufficient estrogen stimulation in the myometrial tissue, sensitive to estrogen. There was a possibility also that the reduction of the enzymic synthesis was caused by energetic deficit on account of insufficient transhydrogenase activity as a result of the reduced estrogen concentrations.
作者检测了用睾酮处理的去卵巢雌性大鼠子宫肌层中谷草转氨酶（GOT）、谷丙转氨酶（GPT）、乳酸脱氢酶（LDH）和醛缩酶（ALD）的活性。与健康大鼠组相比，两个实验组动物的检测酶活性均有所降低。去卵巢大鼠组子宫肌层酶活性的降低比睾酮处理组更为明显。这些结果被解释为子宫肌层组织中对雌激素敏感的蛋白质酶合成减少是由于雌激素刺激不足所致。也有可能是由于雌激素浓度降低导致转氢酶活性不足，进而引起能量缺乏，导致酶合成减少。
