Cruz M E, Preux P M, Debrock C, Cruz I, Schantz P M, Tsang V C, Dumas M
Université San Francisco de Quito, Collège des sciences de la santé, Equateur.
Bull Soc Pathol Exot. 1999 Feb;92(1):38-41.
Taenia solium neurocysticercosis (NCC) has been documented to be an underlying cause of epilepsy, intractable headaches, hydrocephalus, dementia and other serious neurological conditions in many countries of Central and South America. However, methodological limitations had prevented the assessment of the true prevalence of this condition at the community level. We conducted a house-to-house neuroepidemiological survey of 6,118 residents of an Andean community. This information was used to target neuroimaging (CT-scan) and immunodiagnosis (enzyme-linked immunoelectrotransfer blot assay, EITB) tests in individuals suspected of harbouring Taenia solium NCC. In the rural population, NCC was confirmed in 8 out of 47 examined by CT-scan (17%) and in 6 of 42 examined by EITB (14%). In the urban population, NCC was confirmed in 35 of 147 examined by CT-scan (23.8%) and in 28 of 124 examined by EITB (22.6%). In a sample of relatives of patients with documented cerebral cysticercosis, 20 out of 81 examined by CT-scan (25%) and 12 of 79 (15%) examined by EITB had NCC. Finally, CT scans were performed for 83 school children from urban areas, and 9 (11%) were diagnosed as harbouring NCC. In a community-based study, cysticercosis appears to be much more frequent than initially thought, when CT examination is used as the "gold standard" for diagnosis.
在中美洲和南美洲的许多国家，猪带绦虫神经囊尾蚴病（NCC）已被证明是癫痫、顽固性头痛、脑积水、痴呆及其他严重神经系统疾病的潜在病因。然而，方法学上的局限性阻碍了对该疾病在社区层面真实患病率的评估。我们对一个安第斯社区的6118名居民进行了逐户神经流行病学调查。这些信息被用于对疑似感染猪带绦虫NCC的个体进行神经影像学（CT扫描）和免疫诊断（酶联免疫电转移印迹试验，EITB）检测。在农村人口中，47名接受CT扫描的人员中有8人（17%）被确诊为NCC，42名接受EITB检测的人员中有6人（14%）被确诊。在城市人口中，147名接受CT扫描的人员中有35人（23.8%）被确诊为NCC，124名接受EITB检测的人员中有28人（22.6%）被确诊。在有脑囊尾蚴病记录的患者亲属样本中，81名接受CT扫描的人员中有20人（25%）被确诊为NCC，79名接受EITB检测的人员中有12人（15%）被确诊。最后，对83名城市学龄儿童进行了CT扫描，其中9人（11%）被诊断为感染NCC。在一项基于社区的研究中，当CT检查被用作诊断的“金标准”时，囊尾蚴病似乎比最初认为的更为常见。
