Tan P Z, Baldwin R M, Soufer R, Garg P K, Charney D S, Innis R B
VA PET Center, Department of Psychiatry, Yale University School of Medicine, West Haven, CT 06516, USA.
Appl Radiat Isot. 1999 May;50(5):923-7. doi: 10.1016/s0969-8043(98)00150-x.
A complete remote control system was constructed for production of the PET 5-HT2A ligand [18F]altanserin by nitro-for-fluoro exchange. Comparing with published methods, the key features include (1) conducting azeotropic distillation and nucleophilic displacement in an open vessel heated by a commercial microwave oven; (2) purifying the product by a single HPLC procedure and (3) removing HPLC solvent by solid phase extraction. The preparation took 114 min with 23% yield and high quality.
构建了一个完整的遥控系统，用于通过硝基氟交换法生产PET 5-HT2A配体[18F]阿坦色林。与已发表的方法相比，其关键特性包括：（1）在商用微波炉加热的敞口容器中进行共沸蒸馏和亲核取代反应；（2）通过单一的高效液相色谱（HPLC）程序纯化产物；（3）通过固相萃取去除HPLC溶剂。该制备过程耗时114分钟，产率为23%，且质量高。
