Frit P, Bergmann E, Egly J M
Institut de Génétique et de Biologie Moléculaire et Cellulaire, Université Louis-Pasteur, Strasbourg, Illkirch, France.
Biochimie. 1999 Jan-Feb;81(1-2):27-38. doi: 10.1016/s0300-9084(99)80035-2.
TFIIH (transcription factor IIH) is a multiprotein complex consisting of nine subunits initially characterized as a basal transcription factor required for initiation of protein-coding RNA synthesis. TFIIH was the first transcription factor shown to harbor several enzymatic activities, likely indicative of functional complexity. This intricacy was further emphasized with the cloning of the genes encoding the different subunits which disclosed direct connections between transcription, DNA repair and cell cycle regulation. In this review, we emphasize those functions of TFIIH involved in DNA repair, as well as their relationship to TFIIH's roles in transcription, cell cycle control and apoptosis. These connections may prove to be essential for the cellular response to DNA damage.
TFIIH（转录因子IIH）是一种由九个亚基组成的多蛋白复合体，最初被鉴定为蛋白质编码RNA合成起始所需的基础转录因子。TFIIH是首个被证明具有多种酶活性的转录因子，这可能暗示了其功能的复杂性。随着编码不同亚基的基因的克隆，这种复杂性进一步凸显，这些克隆揭示了转录、DNA修复和细胞周期调控之间的直接联系。在本综述中，我们着重阐述TFIIH在DNA修复中的功能，以及它们与TFIIH在转录、细胞周期控制和细胞凋亡中的作用之间的关系。这些联系可能对细胞对DNA损伤的反应至关重要。
