Miyata A, Matsunaga H, Kiriike N, Iwasaki Y, Takei Y, Yamagami S
Department of Neuropsychiatry, Osaka City University Medical School, Osaka, Japan.
Psychiatry Clin Neurosci. 1998 Oct;52(5):513-8. doi: 10.1046/j.1440-1819.1998.00427.x.
Twenty-three unmedicated patients with obsessive-compulsive disorder (OCD) were compared with 12 unmedicated patients with social phobia (SP) and 18 age-matched normal controls (C) using a two-tone auditory oddball event-related potentials (ERP) paradigm. The OCD group showed significantly shorter P300 latencies and shorter N200 latencies for target stimuli than the SP and the C groups. The OCD patients also tended to have greater N200 negativity compared with normal controls. However, there were no significant relationships between these ERP abnormalities in OCD patients and the type or severity of their OCD symptoms. In the mean ERP waveforms, increased N200 negativity for target stimuli, as well as the provocation in the later part of N200 for non-target stimuli, were more commonly observed in the OCD and the SP groups compared with the C group. These results raise the possibility that the shorter N200 and P300 latencies in OCD patients may be an OCD-specific phenomenon that is more closely related to the biological basis for OCD, rather than the characteristics of their OCD symptoms. On the other hand, increased negativity in the N200 region, even for non-target stimuli, may represent the common abnormalities among anxiety disorders.
采用双音听觉oddball事件相关电位（ERP）范式，对23名未接受药物治疗的强迫症（OCD）患者、12名未接受药物治疗的社交恐惧症（SP）患者和18名年龄匹配的正常对照者（C）进行了比较。与SP组和C组相比，OCD组对目标刺激的P300潜伏期和N200潜伏期显著更短。与正常对照者相比，OCD患者的N200负波也往往更大。然而，OCD患者的这些ERP异常与他们OCD症状的类型或严重程度之间没有显著关系。在平均ERP波形中，与C组相比，OCD组和SP组中更常见到目标刺激的N200负波增加，以及非目标刺激在N200后期的激发。这些结果提示，OCD患者较短的N200和P300潜伏期可能是一种OCD特异性现象，与OCD的生物学基础关系更为密切，而非其OCD症状的特征。另一方面，即使对于非目标刺激，N200区域负波增加可能代表焦虑症之间的共同异常。
