Fujii T
Jpn J Pharmacol. 1976 Dec;26(6):751-6. doi: 10.1254/jjp.26.751.
In a previous experiment, fetopathic effects of caffeine were significantly reduced by pretreatment with propranolol at dosage levels of 2.5 to 10 mg/kg. The present experiments were undertaeken to investigate the relation between time intervals of propranolol pretreatment and its effect on reducing fetopathy. Furthermore, the effect of timolol, another beta-adrenergic blocking agent, on reducing fetopathy was compared with that of propranolol. Propranolol (5 mg/kg) administered 15, 30 or 60 minutes before caffeine treatment significantly reduced the caffeine-induced fetopathy. The optimal effect was found when propranolol was given 30 minutes before caffine. The reduction in fetopathy by timolol pretreatment was comparable to that of propranolol. The results lend support to the hypothesis that the fetopathic effect of caffeine is linked with released catecholamines in material or fetal issues of mice.
在之前的一项实验中，在剂量为2.5至10毫克/千克的普萘洛尔预处理后，咖啡因对胎儿的不良影响显著降低。进行本实验是为了研究普萘洛尔预处理的时间间隔与其减少胎儿病变作用之间的关系。此外，还将另一种β-肾上腺素能阻滞剂噻吗洛尔减少胎儿病变的作用与普萘洛尔的作用进行了比较。在咖啡因处理前15、30或60分钟给予普萘洛尔（5毫克/千克）可显著降低咖啡因诱导的胎儿病变。在咖啡因处理前30分钟给予普萘洛尔时发现效果最佳。噻吗洛尔预处理对胎儿病变的减少作用与普萘洛尔相当。这些结果支持了以下假设：咖啡因对胎儿的不良影响与小鼠母体或胎儿组织中释放的儿茶酚胺有关。
