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核心技术专利：CN118964589B侵权必究

核心技术专利：CN118964589B侵权必究

Evemy K L, Cummins P, Littler W A

Clin Sci (Lond). 1981 Jan;60(1):33-40. doi: 10.1042/cs0600033.

The effect of prolonged administration of beta-adrenoreceptor-blocking agents was studied in growing rabbits. Equivalent doses of propranolol and timolol were given parenterally for 8 weeks. 2. Animals given propranolol had a significantly lower heart rate than that in the controls. After subcutaneous injection, plasma propranolol levels were twice those obtained after intraperitoneal injection. 3. Growth rate of animals given propranolol intraperitoneally was significantly less than controls, whereas animals given propranolol subcutaneously or timolol intraperitoneally grew normally. Reduced growth rate was associated with reduced food intake and was not related to the beta-adrenoreceptor-blocking activity of the drugs. 4. At the end of the experiment the heart and other organs were examined. beta-Adrenoreceptor blockade produced no significant changes in ventricular size or water content, and no significant changes in ultrastructure were found.

研究了在生长中的家兔体内长期给予β-肾上腺素能受体阻滞剂的效果。将等效剂量的普萘洛尔和噻吗洛尔经肠胃外途径给药8周。2. 给予普萘洛尔的动物心率显著低于对照组。皮下注射后，血浆普萘洛尔水平是腹腔注射后所得水平的两倍。3. 腹腔注射普萘洛尔的动物生长速率显著低于对照组，而皮下注射普萘洛尔或腹腔注射噻吗洛尔的动物生长正常。生长速率降低与食物摄入量减少有关，且与药物的β-肾上腺素能受体阻断活性无关。4. 在实验结束时，对心脏和其他器官进行了检查。β-肾上腺素能受体阻断未使心室大小或含水量发生显著变化，且未发现超微结构有显著改变。

Evemy K L, Cummins P, Littler W A

Clin Sci (Lond). 1981 Jan;60(1):33-40. doi: 10.1042/cs0600033.

The effect of prolonged administration of beta-adrenoreceptor-blocking agents was studied in growing rabbits. Equivalent doses of propranolol and timolol were given parenterally for 8 weeks. 2. Animals given propranolol had a significantly lower heart rate than that in the controls. After subcutaneous injection, plasma propranolol levels were twice those obtained after intraperitoneal injection. 3. Growth rate of animals given propranolol intraperitoneally was significantly less than controls, whereas animals given propranolol subcutaneously or timolol intraperitoneally grew normally. Reduced growth rate was associated with reduced food intake and was not related to the beta-adrenoreceptor-blocking activity of the drugs. 4. At the end of the experiment the heart and other organs were examined. beta-Adrenoreceptor blockade produced no significant changes in ventricular size or water content, and no significant changes in ultrastructure were found.

研究了在生长中的家兔体内长期给予β-肾上腺素能受体阻滞剂的效果。将等效剂量的普萘洛尔和噻吗洛尔经肠胃外途径给药8周。2. 给予普萘洛尔的动物心率显著低于对照组。皮下注射后，血浆普萘洛尔水平是腹腔注射后所得水平的两倍。3. 腹腔注射普萘洛尔的动物生长速率显著低于对照组，而皮下注射普萘洛尔或腹腔注射噻吗洛尔的动物生长正常。生长速率降低与食物摄入量减少有关，且与药物的β-肾上腺素能受体阻断活性无关。4. 在实验结束时，对心脏和其他器官进行了检查。β-肾上腺素能受体阻断未使心室大小或含水量发生显著变化，且未发现超微结构有显著改变。