Edgren M, Lennernäs B, Larsson A, Nilsson S
Department of Oncology, University Hospital, Uppsala, Sweden.
Anticancer Res. 1999 Jan-Feb;19(1B):869-73.
Sixty nine patients with urogenital cancers (renal, bladder and prostate cancer) were studied to determine whether the serum concentrations of Vascular Endothelial Growth Factor (VEGF) and basic Fibroblast Growth Factor (b-FGF) reflected the status of the patients and/or the prognosis of the disease. Of the patients included in this study, renal cell carcinoma patients expressed the highest levels of VEGF indicating that these tumours are more VEGF dependent. The values of b-FGF could be considered normal in all three malignancies. No correlation was observed between the expression of VEGF and b-FGF, nor between VEGF and b-FGF and patients survival.
对69例泌尿生殖系统癌症（肾癌、膀胱癌和前列腺癌）患者进行了研究，以确定血管内皮生长因子（VEGF）和碱性成纤维细胞生长因子（b-FGF）的血清浓度是否反映患者的病情状况和/或疾病预后。在本研究纳入的患者中，肾细胞癌患者的VEGF水平最高，表明这些肿瘤对VEGF的依赖性更强。在所有这三种恶性肿瘤中，b-FGF的值均可视为正常。未观察到VEGF和b-FGF的表达之间、VEGF和b-FGF与患者生存率之间存在相关性。
