Saitoh H, Kamoda T, Nakahara S, Hirano T, Matsui A
Department of Pediatrics, University of Tsukuba, Japan.
Eur J Endocrinol. 1999 Mar;140(3):231-4. doi: 10.1530/eje.0.1400231.
The present study was undertaken to examine the association of a glucose-stimulated insulin response with the fasting insulin-like growth factor-binding protein (IGFBP)-1 concentration in prepubertal obese children.
The fasting levels of serum insulin and IGFBP-1 were measured in 17 obese and 16 control children. Furthermore, we performed an oral glucose tolerance test in obese children and examined the association of the area under the curve (AUC) for insulin with the fasting IGFBP-1 level.
The mean serum level of IGFBP-1 was significantly lower in obese children (41.0 +/- 4.8 micrograms/l. P < 0.005) than in controls (91.2 +/- 9.9 micrograms/l). Although there was an inverse relationship between the fasting levels of serum insulin and IGFBP-1 in all subjects (r = -0.42, P < 0.05), no significant correlation between these two parameters was observed in the obese group alone. In obese children, the fasting IGFBP-1 level correlated inversely with AUC-insulin (r = -0.70, P < 0.005), whereas there was no significant relationship between the fasting insulin level and AUC-insulin.
The present study suggests that the serum level of IGFBP-1 may be an early predictor of insulin resistance in prepubertal obesity.
本研究旨在探讨青春期前肥胖儿童葡萄糖刺激的胰岛素反应与空腹胰岛素样生长因子结合蛋白（IGFBP）-1浓度之间的关联。
测定了17名肥胖儿童和16名对照儿童的空腹血清胰岛素和IGFBP-1水平。此外，我们对肥胖儿童进行了口服葡萄糖耐量试验，并检测了胰岛素曲线下面积（AUC）与空腹IGFBP-1水平之间的关联。
肥胖儿童的平均血清IGFBP-1水平（41.0±4.8微克/升，P<0.005）显著低于对照组（91.2±9.9微克/升）。虽然所有受试者的空腹血清胰岛素水平与IGFBP-1之间呈负相关（r=-0.42，P<0.05），但仅在肥胖组中未观察到这两个参数之间的显著相关性。在肥胖儿童中，空腹IGFBP-1水平与AUC-胰岛素呈负相关（r=-0.70，P<0.005），而空腹胰岛素水平与AUC-胰岛素之间无显著关系。
本研究表明，IGFBP-1的血清水平可能是青春期前肥胖中胰岛素抵抗的早期预测指标。
