Phadke M A, Bhargava I, Dhaigude P, Bagade A, Biniwale M A, Kurlekar S U
Department of Pediatrics, B.J. Medical College, Pune, India.
Indian Pediatr. 1998 Aug;35(8):723-5.
To compare the efficacy of two dose and single dose measles vaccination in a community setting.
Two community ICDS blocks with populations of 8990 and 8550 children below 12 years of age were selected. Block A had 1560 children between 9 mo to 1 year of age and Block B had 1380 children between the age of 9 mo to 1 year.
All eligible children between 9 mo to 1 year of age were given measles vaccination in October 1994. Only the children in Group A were given a second dose of measles (as MMR) in April 1995; six months after the first dose. A survey was undertaken from January 1996 to April 1996 to clinically evaluate the number of cases of measles in both these blocks.
In Block A 3 children developed measles, whereas in Block B, there were 16 cases of measles (p < 0.01). All other parameters in both groups, e.g., cold chain maintenance were similar.
This study supports the superiority of two dose measles vaccination given at an interval of 6 months over a single dose measles in a community setting.
比较在社区环境中两剂次和单剂次麻疹疫苗接种的效果。
选取了两个社区综合儿童发展服务中心区域，分别有8990名和8550名12岁以下儿童。A区有1560名9个月至1岁的儿童，B区有1380名9个月至1岁的儿童。
1994年10月，所有9个月至1岁的符合条件的儿童均接种麻疹疫苗。只有A组儿童在1995年4月，即第一剂接种6个月后，接种了第二剂麻疹疫苗（作为麻腮风三联疫苗）。1996年1月至1996年4月进行了一项调查，以临床评估这两个区域麻疹病例的数量。
A区有3名儿童患麻疹，而B区有16例麻疹病例（p<0.01）。两组的所有其他参数，如冷链维护情况相似。
本研究支持在社区环境中，间隔6个月接种两剂次麻疹疫苗比单剂次麻疹疫苗更具优势。
