van 't Spijker C, Rümke H C
Kruiswerk Lek en Merwede, Gorinchem.
Ned Tijdschr Geneeskd. 1994 Nov 26;138(48):2400-5.
To assess the value of an alternative vaccination programme (VP) with Mumps-Measles-Rubella (MMR) vaccine at the ages of 12 and 15 months compared with the standard VP (MMR at the ages of 14-15 months and 9 years).
Cross-sectional study.
The area of activity of the 'Lek and Merwede' Extramural Health Care Department.
Data from general practitioners (GPs) and from an inquiry among parents of 873 children born in a 1.5 year period (randomly taken among 4500 children) and given the alternative MMR VP, were used. The inquiry took place during a measles epidemic in 1993. A non-response study was also executed among the parents.
The response of the GPs was low (14 cases reported by 8 out of 90 GPs). Eighty-two per cent of the parents responded. There was no correlation between (non-)response and the alternative VP. The vaccination was effective and no significant differences between standard and alternative VP were found.
Vaccination protects against measles. An alternative VP could theoretically be more effective, but because of the excellent results of the standard VP differences could not be detected.
评估与标准疫苗接种计划（14 - 15个月和9岁时接种麻疹-腮腺炎-风疹（MMR）疫苗）相比，在12个月和15个月龄时接种MMR疫苗的替代疫苗接种计划（VP）的价值。
横断面研究。
“莱克和默韦德”校外医疗保健部门的活动区域。
使用来自全科医生（GP）的数据以及对在1.5年期间出生的873名儿童（从4500名儿童中随机抽取）的父母进行询问的数据，这些儿童接种了替代的MMR疫苗接种计划。该询问在1993年麻疹流行期间进行。还对父母进行了无应答研究。
全科医生的应答率较低（90名全科医生中有8名报告了14例病例）。82%的父母做出了回应。（无）应答与替代疫苗接种计划之间没有相关性。疫苗接种是有效的，并且未发现标准疫苗接种计划和替代疫苗接种计划之间存在显著差异。
疫苗接种可预防麻疹。理论上替代疫苗接种计划可能更有效，但由于标准疫苗接种计划效果极佳，未检测到差异。
