高同型半胱氨酸血症：儿童缺血性卒中的一个危险因素。
Hyperhomocysteinemia: a risk factor for ischemic stroke in children.
作者信息
van Beynum I M, Smeitink J A, den Heijer M, te Poele Pothoff M T, Blom H J
机构信息
University Hospital Nijmegen, The Netherlands.
出版信息
Circulation. 1999 Apr 27;99(16):2070-2. doi: 10.1161/01.cir.99.16.2070.
BACKGROUND
Moderate hyperhomocysteinemia is a risk factor for arterial vascular disease and venous thrombosis in adults. We performed a case-control study to assess a possible relation between moderate hyperhomocysteinemia and ischemic stroke in Dutch children (age range, 0 to 18 years).
METHODS AND RESULTS
We measured plasma total homocysteine levels (tHcy) in 45 patients with ischemic stroke and in 234 controls. Hyperhomocysteinemia was defined as a tHcy above the 95th percentile regression line for the respective age of the controls. Hyperhomocysteinemia was present in 8 (18%) of the 45 patients with ischemic stroke. The odds ratio was 4.4 (95% CI, 1.7 to 11.6).
CONCLUSIONS
We conclude that moderate hyperhomocysteinemia is a risk factor for ischemic stroke in children.
背景
中度高同型半胱氨酸血症是成人动脉血管疾病和静脉血栓形成的危险因素。我们进行了一项病例对照研究，以评估荷兰儿童（年龄范围为0至18岁）中度高同型半胱氨酸血症与缺血性中风之间的可能关系。
方法与结果
我们测量了45例缺血性中风患者和234例对照者的血浆总同型半胱氨酸水平（tHcy）。高同型半胱氨酸血症定义为tHcy高于对照组相应年龄的第95百分位回归线。45例缺血性中风患者中有8例（18%）存在高同型半胱氨酸血症。优势比为4.4（95%可信区间，1.7至11.6）。
结论
我们得出结论，中度高同型半胱氨酸血症是儿童缺血性中风的危险因素。
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