观点：病毒感染与神经元死亡
Perspective: virus infections and the death of neurons.
作者信息
Griffin D E, Hardwick J M
机构信息
Dept of Molecular Microbiology and Immunology, Johns Hopkins University School of Hygiene and Public Health, 615 N. Wolfe St, Baltimore, MD 21205,
出版信息
Trends Microbiol. 1999 Apr;7(4):155-60. doi: 10.1016/s0966-842x(99)01470-5.
Abstract
Neuronotropic viruses induce apoptosis in neurons, and Bcl-2-related anti-apoptotic proteins and caspase inhibitors decrease mortality from acute viral encephalitis. Infected neurons develop cytoplasmic blebbing characteristic of apoptosis, but a paucity of apoptotic nuclear changes potentially indicates unique aspects of virus-induced neuronal apoptosis that remain to be discovered.
摘要
嗜神经病毒可诱导神经元凋亡，而Bcl-2相关抗凋亡蛋白和半胱天冬酶抑制剂可降低急性病毒性脑炎的死亡率。受感染的神经元会出现凋亡特有的细胞质起泡现象，但凋亡性核变化较少，这可能表明病毒诱导的神经元凋亡存在尚待发现的独特方面。
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