Everett H, McFadden G
Dept of Biochemistry, University of Alberta, Edmonton, Alberta, Canada T6G 2H7.
Trends Microbiol. 1999 Apr;7(4):160-5. doi: 10.1016/s0966-842x(99)01487-0.
Viruses can induce apoptosis of infected cells either directly, to assist virus dissemination, or by inadvertently triggering cellular sensors that initiate cell death. Cellular checkpoints that can function as 'alarm bells' to transmit pro-apoptotic signals in response to virus infections include death receptors, protein kinase R, mitochondrial membrane potential, p53 and the endoplasmic reticulum.
病毒可直接诱导受感染细胞凋亡以促进病毒传播，或因意外触发启动细胞死亡的细胞传感器而诱导凋亡。可作为“警钟”以响应病毒感染传递促凋亡信号的细胞检查点包括死亡受体、蛋白激酶R、线粒体膜电位、p53和内质网。
