Medina Pérez M, Valpuesta Fernández I, Valero Puerta J, Pérez Martín D
Servicio de Anatomía Patológica, Hospital de la Merced, Osuna, Sevilla, España.
Arch Esp Urol. 1999 Mar;52(2):169-70.
To report a rare case of scrotal granular cell tumor.
A 19-year-old man presented with a nodule on the scrotum, 2 cm in diameter. It had been present for months and was covered with ulcerated epidermis. The tumor was resected.
The histological study disclosed a neoplasm composed of polygonal cells with cytoplasmic granules and pseudoepitheliomatous hyperplasia of the overlying skin. Immunohistochemically, the cells showed a strong positivity for S100 protein and vimentin. The proliferation index (ki 67) was low in its cells, but high in the overlying hyperplasic epidermal cells.
To our knowledge, this is the second case of scrotal granular cell tumor reported. The case described herein has the unique feature of severe overlying pseudoepitheliomatous hyperplasia. S100 positivity supports a neurogenic differentiation.
报告一例罕见的阴囊颗粒细胞瘤病例。
一名19岁男性阴囊出现一个直径2厘米的结节，已存在数月，表面表皮溃疡。对该肿瘤进行了切除。
组织学研究显示肿瘤由具有胞质颗粒的多边形细胞组成，其上方皮肤呈假上皮瘤样增生。免疫组化显示，细胞对S100蛋白和波形蛋白呈强阳性。其细胞增殖指数（ki 67）较低，但上方增生的表皮细胞中较高。
据我们所知，这是报告的第二例阴囊颗粒细胞瘤病例。本文所述病例具有严重的上方假上皮瘤样增生这一独特特征。S100阳性支持神经源性分化。
