Richmond Abby M, La Rosa Francisco G, Said Sherif
Department of Pathology, University of Colorado Anschutz Medical Campus, Aurora, CO, 80045, USA.
Department of Pathology, Denver Health Hospital, Denver, CO, 80204, USA.
J Med Case Rep. 2016 Jun 4;10(1):161. doi: 10.1186/s13256-016-0911-x.
Granular cell tumors are neoplasms of Schwann cell origin. They typically arise in the head and neck of adults, with the tongue being the most common location; granular cell tumors of male genitalia are exceedingly rare. We identified only eight prior cases of scrotal granular cell tumor in the literature, and only one was in a child. Herein, we report a second case of childhood scrotal granular cell tumor and provide a review of the most relevant literature.
A fifteen-year-old hispanic boy was referred to our hospital's pediatric surgery service for a painless and firm scrotal mass. Clinical impression was that of an epidermal inclusion cyst. There was no evidence of associated medical problems from the clinical history and physical examination. Surgical enucleation of the lesion demonstrated a solid nodule with morphological and immunohistochemical features consistent with a benign granular cell tumor.
This is the second case reported of a scrotal granular cell tumor in a child. Although genital granular cell tumors are rare, and most are benign, careful clinical examination, complete surgical excision, expert histologic evaluation, and a close follow-up are recommended for accurate diagnosis and to rule out eventual malignancy.
颗粒细胞瘤是起源于施万细胞的肿瘤。它们通常发生于成人的头颈部，其中舌头是最常见的发病部位；男性生殖器的颗粒细胞瘤极为罕见。我们在文献中仅发现8例阴囊颗粒细胞瘤的既往病例，且仅有1例发生于儿童。在此，我们报告第二例儿童阴囊颗粒细胞瘤病例，并对最相关的文献进行综述。
一名15岁的西班牙裔男孩因阴囊无痛性实性肿块被转诊至我院小儿外科。临床诊断为表皮样囊肿。临床病史和体格检查未发现相关的内科问题。对该病变进行手术摘除，结果显示为一个实性结节，其形态和免疫组化特征与良性颗粒细胞瘤一致。
这是第二例报道的儿童阴囊颗粒细胞瘤病例。尽管生殖器颗粒细胞瘤罕见，且大多数为良性，但仍建议进行仔细的临床检查、完整的手术切除、专业的组织学评估及密切随访，以实现准确诊断并排除最终恶变的可能。
