Dasgupta D J, Garg I D, Kaushal S S, Chauhan S, Sharma A, Goyal A
Department of Medicine, Indira Gandhi Medical College, Shimla.
J Indian Med Assoc. 1998 Nov;96(11):338-40.
Ten patients of chronic obstructive pulmonary disease were studied for changes in ultrastructure of the glomeruli, serum immunoglobulin and complement levels. The glomeruli showed proliferation in the mesangium in 90% patients and electron dense deposits in the mesangium in 30% patients. IgA and IgG were usually elevated whereas complements were usually depressed in most of these patients. It is suggested that repeated respiratory infections in these subjects may be responsible for mesangioproliferative type of glomerulonephritis, high IgA and IgG levels. The complements are activated and they take part in immune complex formation getting deposited in mesangium.
对10例慢性阻塞性肺疾病患者进行了肾小球超微结构、血清免疫球蛋白及补体水平变化的研究。90%的患者肾小球系膜增生，30%的患者系膜有电子致密沉积物。在大多数这些患者中，IgA和IgG通常升高，而补体通常降低。提示这些患者反复呼吸道感染可能是系膜增生型肾小球肾炎、高IgA和IgG水平的原因。补体被激活并参与免疫复合物形成，沉积于系膜。
