Kim C K, Aikawa M, Makker S P
Arch Pathol Lab Med. 1979 Oct;103(11):595-8.
A case of Henoch-Schönlein purpura (HSP) with renal lesions is presented. The clinical, laboratory, and morphologic findings revealed features commonly described in HSP. A renal biopsy revealed diffuse, generalized, proliferative glomerulonephritis. The unusual findings in this case were numerous electron-dense subepithelial deposits ("humps") and a few small intramembranous deposits in the glomerular capillaries without deposits in the mesangium, mimicking those of acute poststreptococcal glomerulonephritis. The electron-dense deposits were well correlated with deposits of IgG, IgA, C3, C4, C1q, and fibrin-fibrinogen demonstrated by immunofluorescent microscopy.
本文报告一例伴有肾脏损害的过敏性紫癜（HSP）。临床、实验室及形态学检查结果显示出HSP常见的特征。肾脏活检显示为弥漫性、全身性、增殖性肾小球肾炎。该病例的不寻常发现为肾小球毛细血管中有大量电子致密的上皮下沉积物（“驼峰”）及少量小的膜内沉积物，而系膜中无沉积物，类似急性链球菌感染后肾小球肾炎。电子致密沉积物与免疫荧光显微镜显示的IgG、IgA、C3、C4、C1q及纤维蛋白-纤维蛋白原沉积物高度相关。
