van Ginneken E E, van der Meer J W, Netten P M
Department of Internal Medicine, Bosch Medicentrum, ME's Hertogenbosch, The Netherlands.
Neth J Med. 1999 Apr;54(4):158-62. doi: 10.1016/s0300-2977(98)00140-5.
We have observed a 26-year-old diabetic male who had been treated with carbamazepine because of seizures. After two months of treatment, he developed a severe illness with skin rash, fever, hepatomegaly and hypogammaglobulinaemia. Since hypogammaglobulinaemia is a rare side effect of carbamazepine treatment, a stop order was given for carbamazepine. The abnormalities (skin, fever, hypogammaglobulinaemia) remained until it appeared that the patient had secretly continued taking the drug. When drug administration was stopped the skin abnormalities improved and serum immunoglobulin levels became normal. The etiology of this transient carbamazepine-induced hypogammaglobulinaemia is unknown.
我们观察了一名26岁的糖尿病男性，他因癫痫发作接受卡马西平治疗。治疗两个月后，他患上了一种严重疾病，出现皮疹、发热、肝肿大和低丙种球蛋白血症。由于低丙种球蛋白血症是卡马西平治疗罕见的副作用，因此停用了卡马西平。这些异常情况（皮肤、发热、低丙种球蛋白血症）一直存在，直到发现患者偷偷继续服药。停药后皮肤异常情况有所改善，血清免疫球蛋白水平恢复正常。这种由卡马西平引起的短暂性低丙种球蛋白血症的病因尚不清楚。
