Bezmialem Vakif University, Istanbul, Turkey.
Seizure. 2012 Apr;21(3):229-31. doi: 10.1016/j.seizure.2011.12.013. Epub 2012 Jan 16.
Carbamazepine is used to control seizures. Its common side effects are sleep disorders, anorexia, nausea, vomiting, polydipsia, irritability, ataxia, and diplopia. Involvement of the immune system is rare, and few cases of decreased immunoglobulin levels have been reported. We describe a patient with low immunoglobulin levels due to carbamazepine use who presented with recurrent urinary tract infection. Intravenous immunoglobulin was administered, and immunoglobulin levels increased to safer levels after discontinuation of carbamazepine. Previous reports describe severe infection after carbamazepine-induced hypogammaglobulinemia. Therefore, in patients using antiepileptics, particularly carbamazepine, serum immunoglobulin levels should be checked in those with recurrent infections.
卡马西平用于控制癫痫发作。其常见的副作用有睡眠障碍、食欲不振、恶心、呕吐、多尿、易激惹、共济失调和复视。免疫系统受累罕见，仅有少数报道称免疫球蛋白水平降低。我们描述了一例因使用卡马西平导致免疫球蛋白水平降低的患者，该患者因反复尿路感染就诊。给予患者静脉注射免疫球蛋白，停用卡马西平后免疫球蛋白水平升高至更安全的水平。先前的报告描述了卡马西平诱导的低丙种球蛋白血症后严重感染的情况。因此，在使用抗癫痫药（尤其是卡马西平）的患者中，对于反复感染的患者应检查血清免疫球蛋白水平。
