Honma Y, Kiyosawa H, Mori T, Oguri A, Nikaido T, Kanazawa K, Tojo M, Takeda J, Tanno Y, Yokoya S, Kawabata I, Ikeda H, Wanaka A
Department of Cell Science, Institute of Biomedical Sciences, Fukushima Medical University School of Medicine, Fukushima City, Japan.
FEBS Lett. 1999 Mar 19;447(1):76-80. doi: 10.1016/s0014-5793(99)00265-3.
We identified a novel member of the Ikaros gene family, which has critical roles in the development of lymphoid lineages. This gene, which we named Eos, was expressed predominantly in the developing central and peripheral nervous system. Eos protein could interact with itself and Ikaros protein through its C-terminal portion in the yeast two hybrid assay. These findings suggested that Eos may have important roles in neural development similarly to the Ikaros family in the development of hemolymphoid tissue.
我们鉴定出了伊卡洛斯基因家族的一个新成员，它在淋巴谱系发育中起关键作用。我们将这个基因命名为Eos，它主要在发育中的中枢和外周神经系统中表达。在酵母双杂交试验中，Eos蛋白可通过其C末端部分与自身及伊卡洛斯蛋白相互作用。这些发现表明，Eos可能在神经发育中具有重要作用，类似于伊卡洛斯家族在血淋巴组织发育中的作用。
