Martynenko F P, Zriakov O N
Ukr Biokhim Zh. 1976 Sep-Oct;48(5):584-6.
The content of serotonin in hypothalamus of thyroidectomized rats is twice as low on the 5th day and twice as high on the 14th day after the operation as in the intact animals. Specific radioactivity of serotonin after subarachnoid administration of tryptophan-14C an hour before killing is twice as high on the 5th day and twice as low on the 14th day. Exogenous somatotropin prevents from the mentioned changes on the 5th day. A conclusion is drawn that the changes in serotonin metabolism in the hypothalamus of rats after thyroidectomy is mainly determined by the changes in the level of somatotropin in the organism.
甲状腺切除术后第5天，大鼠下丘脑血清素含量比正常动物低一半，而术后第14天则比正常动物高一倍。处死前一小时经蛛网膜下腔注射14C-色氨酸后，血清素的比放射性在第5天高一半，在第14天低一半。外源性生长激素可防止第5天出现上述变化。由此得出结论，甲状腺切除术后大鼠下丘脑血清素代谢的变化主要由机体中生长激素水平的变化决定。
