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[甲状腺功能减退和亢进大鼠下丘脑的生长激素释放活性]

[Somatotropin-releasing activity of rat hypothalamus with hypo- and hyperthyroidism].

作者信息

Martynenko F P, Rozhko O T

出版信息

Ukr Biokhim Zh (1978). 1978 Jan-Feb;50(1):81-4.

PMID:625816
Abstract

The somatotropin-releasing activity of rat hypothalamus was studied in the experiments in vitro incubating of adenohypophysis with the hypothalamic extracts or the whole hypothalamus and serotonin. The studied activity is shown to be increased in the thyroidectomized and hyperthyroid rats. Exogenic somatotropin prevents this increase. A conclusion is drawn that a link of hypothalamic adenohypophysotropic hormones of the regulatory system of the somatotropic function is not an area of the specific disturbances with hypo- and hyperthyroidism which might lead to hyposomatotropism.

摘要

通过体外将腺垂体与下丘脑提取物、全下丘脑以及血清素共同孵育的实验,对大鼠下丘脑的生长激素释放活性进行了研究。结果显示,在甲状腺切除的大鼠和甲状腺功能亢进的大鼠中,所研究的活性有所增加。外源性生长激素可阻止这种增加。由此得出结论,生长激素功能调节系统中下丘脑-腺垂体促激素的联系并非甲状腺功能减退和亢进时可能导致生长激素分泌不足的特定紊乱区域。

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