Maor-Kendler Y, Gabay G, Bernheim J, Naftali T, Lesin I, Leichtman G, Pomeranz I, Novis B
Institutes of Gastroenterology and Pathology, Meir Hospital, Sapir Medical Center, Kfar-Sava, Israel.
Dig Dis Sci. 1999 Apr;44(4):680-5. doi: 10.1023/a:1026641204860.
Chronic atrophic gastritis can be induced either by H. pylori or by an autoimmune process. The protein product of bcl-2, which is a protooncogene, blocks apoptosis. Aberrant bcl-2 expression has been found in 68% of atrophic gastritis patients. The aim of this study was to compare bcl-2 expression in 20 autoimmune atrophic gastritis patients to that in 20 H. pylori-associated atrophic gastritis patients. Twenty patients with H. pylori antral gastritis but without atrophy served as controls. The bcl-2 expression was assessed by immunohistochemical staining of gastric biopsies, using mouse anti-human bcl-2 monoclonal antibodies. Autoimmune atrophic gastritis patients were younger, mainly females, with a significantly higher serum gastrin level than the H. pylori-associated atrophic gastritis group (P < 0.001). The bcl-2 was expressed in 10/20 (50%) of autoimmune atrophic gastritis patients, in 9/20 (45%) of H. pylori-associated atrophic gastritis patients (P = 0.73), and in 2/20 (10%) of controls. There was no correlation between bcl-2 expression and the presence of intestinal metaplasia (P = 0.35). Our findings confirm that H. pylori-associated atrophic gastritis and autoimmune atrophic gastritis are two different conditions, but with equal expression of bcl-2. Excessive expression of bcl-2 is found only in atrophic gastritis, but not in H. pylori antral gastritis without atrophy.
慢性萎缩性胃炎可由幽门螺杆菌或自身免疫过程诱发。bcl-2是一种原癌基因，其蛋白产物可阻止细胞凋亡。在68%的萎缩性胃炎患者中发现了异常的bcl-2表达。本研究的目的是比较20例自身免疫性萎缩性胃炎患者与20例幽门螺杆菌相关性萎缩性胃炎患者的bcl-2表达情况。20例患有幽门螺杆菌性胃窦炎但无萎缩的患者作为对照。采用小鼠抗人bcl-2单克隆抗体，通过胃活检组织的免疫组化染色评估bcl-2表达。自身免疫性萎缩性胃炎患者较年轻，以女性为主，血清胃泌素水平显著高于幽门螺杆菌相关性萎缩性胃炎组（P < 0.001）。bcl-2在20例自身免疫性萎缩性胃炎患者中的10例（50%）、20例幽门螺杆菌相关性萎缩性胃炎患者中的9例（45%）（P = 0.73）以及20例对照中的2例（10%）中表达。bcl-2表达与肠化生的存在之间无相关性（P = 0.35）。我们的研究结果证实，幽门螺杆菌相关性萎缩性胃炎和自身免疫性萎缩性胃炎是两种不同的疾病，但bcl-2表达水平相当。bcl-2过度表达仅见于萎缩性胃炎，而在无萎缩的幽门螺杆菌性胃窦炎中未发现。
