Klintworth G K, Bredehoeft S J, Reed J W
Am J Ophthalmol. 1978 Sep;86(3):303-13. doi: 10.1016/0002-9394(78)90230-1.
A 46-year old woman and a 59-year-old man had corneal crystals, multiple myeloma, and IgG kappa hypergammaglobulinemia. In one case, crystalline deposits were also present in the lens. In both patients there was a marked decrease in the amount of crystals during chemotherapy. The crystals within the cornea of one case were identified by light and electron microscopy in material obtained during a lamellar keratoplasty. The crystalline deposits were located only in the corneal epithelium, and their regular repeating internal arrangement was confirmed by monochromatic optical diffraction of electron micrographs of sections through them. By immunofluorescent and immunoperoxidase techniques, the crystals reacted positively for immunoglobulin and particularly IgG kappa chains.
一名46岁女性和一名59岁男性患有角膜晶体、多发性骨髓瘤和IgG κ型高球蛋白血症。在其中一例中，晶状体中也存在晶体沉积物。两名患者在化疗期间晶体数量均显著减少。其中一例患者角膜内的晶体在板层角膜移植术中获取的材料中通过光镜和电镜得以鉴定。晶体沉积物仅位于角膜上皮，通过对其切片的电子显微镜照片进行单色光学衍射证实了它们内部规则的重复排列。通过免疫荧光和免疫过氧化物酶技术，晶体对免疫球蛋白尤其是IgG κ链呈阳性反应。
