Lee I S, Jung K Y, Oh S R, Park S H, Ahn K S, Lee H K
Biotechnology Research Division, Korea Research Institute of Bioscience and Biotechnology, Taejon.
Biol Pharm Bull. 1999 Mar;22(3):265-7. doi: 10.1248/bpb.22.265.
We studied the structure-activity relationships of lignans from Schisandra chinensis and their derivatives as platelet activating factor (PAF) antagonists. Strong activity was shown in lignans without an ester group at C-6, a hydroxyl group at C-7 or a methylene dioxy moiety and with an R-biphenyl configuration. 6(7)-Dehydroschisandrol A, a derivative of schisandrol A, showed the highest activity (IC50, 2.1x10(-6) M) in this study.
我们研究了五味子木脂素及其衍生物作为血小板活化因子（PAF）拮抗剂的构效关系。在C-6位无酯基、C-7位有羟基或亚甲二氧基部分且具有R-联苯构型的木脂素中显示出强活性。五味子醇A的衍生物6(7)-脱氢五味子醇A在本研究中表现出最高活性（IC50，2.1×10(-6) M）。
