Reeder J C, Cowman A F, Davern K M, Beeson J G, Thompson J K, Rogerson S J, Brown G V
The Walter and Eliza Hall Institute of Medical Research, Post Office Royal Melbourne Hospital, Victoria 3050, Australia.
Proc Natl Acad Sci U S A. 1999 Apr 27;96(9):5198-202. doi: 10.1073/pnas.96.9.5198.
Chondroitin sulfate A (CSA) is an important receptor for the sequestration of Plasmodium falciparum in the placenta, but the parasite ligand involved in adhesion has not previously been identified. Here we report the identification of a var gene transcribed in association with binding to CSA and present evidence that the P. falciparum erythrocyte membrane protein 1 product of the gene is the parasite ligand mediating CSA binding. Description of this gene and the implication of P. falciparum erythrocyte membrane protein 1 as the parasite ligand paves the way to a more detailed understanding of the pathogenesis of placental infection and potential therapeutic strategies targeting the interaction.
硫酸软骨素A（CSA）是疟原虫在胎盘内滞留的重要受体，但此前尚未鉴定出参与黏附的寄生虫配体。在此，我们报告了一个与结合CSA相关转录的var基因的鉴定，并提供证据表明该基因的恶性疟原虫红细胞膜蛋白1产物是介导CSA结合的寄生虫配体。对该基因的描述以及恶性疟原虫红细胞膜蛋白1作为寄生虫配体的意义，为更详细地了解胎盘感染的发病机制以及针对该相互作用的潜在治疗策略铺平了道路。
