肿瘤诱导的免疫抑制。
Tumor-induced immunosuppression.
作者信息
Friedman H, Specter S, Watanabe M, Pan S H
出版信息
Am J Pathol. 1978 Nov;93(2):499-514.
Abstract
Three tumor systems, including a mastocytoma, plasmacytomas, and a leukemia-lymphoma were studied for their ability to modify humoral immunity to sheep erythrocytes both in vivo and in vitro. All tumors resulted in a depression of the hemolytic antibody plaque-forming cell response in susceptible mice. These studies indicated that the mechanism(s) of suppression, although not fully defined, were different for each model system investigated.
摘要
对三种肿瘤系统进行了研究，包括肥大细胞瘤、浆细胞瘤以及白血病 - 淋巴瘤，以考察它们在体内和体外改变对绵羊红细胞体液免疫的能力。所有肿瘤均导致易感小鼠溶血抗体空斑形成细胞反应受到抑制。这些研究表明，尽管抑制机制尚未完全明确，但在所研究的每个模型系统中，其抑制机制是不同的。
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本文引用的文献
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The role of RNA in the immunological deficiency of plasmacytoma.
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Tumor virus effects on immunocyte precursor cells. Hemopoietic stem cell behavior and leukemogenic susceptibility.肿瘤病毒对免疫细胞前体细胞的影响。造血干细胞行为与白血病易感性。
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