Mevius D J, Sprenger M J, Wegener H C
Department of Bacteriology, Institute for Animal Science and Health, Lelystad, The Netherlands.
Int J Antimicrob Agents. 1999 Feb;11(2):101-5. doi: 10.1016/s0924-8579(98)00093-4.
A global or European strategy should be developed to deal with increasing antimicrobial resistance. This strategy includes surveillance of antimicrobial resistance and monitoring of the use of antimicrobial agents in animals and humans. In animals, surveillance should be focussed on potential transfer of resistant, zoonotic, food-born pathogens and resistance genes to humans. In humans the surveillance should be clinically relevant. Guidelines for rational therapy should be implemented and 'antibiotic teams' should be installed in each hospital to evaluate the prescription of antibiotics and its compliance with guidelines. Keeping animals for food production involves the responsibility for their well being. This includes treatment of infections. However, the use of feed additive, growth-promoting antimicrobials related to therapeutics in human medicine, should be banned immediately. Research aimed at intervention strategies for antimicrobial resistance should be given a high priority with adequate financing both nationally and in Europe. Well co-ordinated European research programmes should have priority; this includes the need to install a European multidisciplinary scientific advisory group.
应制定一项全球或欧洲战略,以应对日益增加的抗菌药物耐药性。该战略包括对抗菌药物耐药性的监测以及对动物和人类抗菌药物使用情况的监测。在动物方面,监测应集中于耐药性、人畜共患病、食源性病原体以及耐药基因向人类的潜在转移。在人类方面,监测应具有临床相关性。应实施合理治疗指南,每家医院都应设立“抗生素小组”,以评估抗生素的处方及其与指南的符合情况。饲养用于食品生产的动物涉及对其健康负责。这包括感染治疗。然而,应立即禁止使用与人类医学治疗相关的饲料添加剂、促生长抗菌药物。应高度重视旨在对抗菌药物耐药性采取干预策略的研究,并在国家和欧洲层面提供充足资金。协调良好的欧洲研究项目应具有优先地位;这包括需要设立一个欧洲多学科科学咨询小组。