美国医生中雄激素受体基因内的CAG重复序列与良性前列腺增生手术发生率
CAG repeat within the androgen receptor gene and incidence of surgery for benign prostatic hyperplasia in U.S. physicians.
作者信息
Giovannucci E, Stampfer M J, Chan A, Krithivas K, Gann P H, Hennekens C H, Kantoff P W
机构信息
Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts, USA.
出版信息
Prostate. 1999 May;39(2):130-4. doi: 10.1002/(sici)1097-0045(19990501)39:2<130::aid-pros8>3.0.co;2-#.
BACKGROUND
CAG repeat length in exon 1 of the androgen receptor (AR) gene correlates inversely with transcriptional transactivation activity of the AR. Men with shorter AR CAG repeat lengths are at higher risk of prostate cancer. Because benign prostatic hyperplasia (BPH) is an androgen-dependent condition, we examined the hypothesis that a shorter AR gene CAG repeat length increases the risk of developing of BPH.
METHODS
Among 14,916 men of the Physicians' Health Study who had provided a blood sample in 1982, we measured AR gene CAG repeat lengths for 310 men who had surgery for BPH up to 7.5 years of follow-up and 1,041 controls.
RESULTS
Risk of surgery for BPH increased linearly with decreasing AR CAG repeat length (P (trend) = 0.03). Relative to men with a CAG repeat length > or = 25, men with a repeat length < or = 19 had an odds ratio of BPH surgery of 1.76 (95% confidence interval, 1.16-2.65).
CONCLUSIONS
Variability in the AR gene CAG repeat influences the development of symptomatic BPH.
背景
雄激素受体（AR）基因外显子1中的CAG重复长度与AR的转录激活活性呈负相关。AR基因CAG重复长度较短的男性患前列腺癌的风险更高。由于良性前列腺增生（BPH）是一种雄激素依赖的疾病，我们检验了以下假设：AR基因CAG重复长度较短会增加患BPH的风险。
方法
在1982年提供血样的医师健康研究中的14916名男性中，我们测量了310名接受BPH手术且随访长达7.5年的男性和1041名对照者的AR基因CAG重复长度。
结果
BPH手术风险随AR基因CAG重复长度的缩短呈线性增加（P（趋势）=0.03）。与CAG重复长度≥25的男性相比，重复长度≤19的男性进行BPH手术的比值比为1.76（95%可信区间，1.16-2.65）。
结论
AR基因CAG重复的变异性影响有症状BPH的发生。
Zotero 插件