Department of Internal Medicine, Inje University Seoul Paik Hospital, Seoul, Korea.
Department of Urology, Gachon University Gil Medical Center, Incheon, Korea.
Investig Clin Urol. 2022 Mar;63(2):192-200. doi: 10.4111/icu.20210382.
The second-to-fourth digit ratio (digit ratio), which is determined , is associated with exposure to visible sunlight during early pregnancy and the season of birth. The digit ratio is also associated with benign prostatic hyperplasia (BPH) and prostate cancer. This suggests that BPH and prostate cancer may be related to the birth season. Therefore, this study aimed to determine whether prostate volume and prostate cancer were related to the birth season.
A total of 858 male patients with lower urinary tract symptoms were enrolled. The right digit ratio was measured, and the month of birth was surveyed. Serum prostate-specific antigen (PSA) levels were measured, and prostate volumes were measured by transrectal ultrasonography. Patients with suspected prostate cancer underwent prostate biopsy.
The mean age, digit ratio, prostate volume, and serum PSA level of 858 patients were 61.6 years, 0.947, 36.2 mL, and 4.24 ng/mL, respectively. Age, serum PSA levels, prostate biopsy rates, and cancer detection rates did not differ significantly according to the birth season. However, compared with the summer birth group, the winter birth group had lower digit ratios (0.951±0.040 vs. 0.941±0.040; p=0.014), larger prostate volumes (33.4±14.9 mL vs. 38.2±20.7 mL; p=0.008), and more prostate cancer (5.3% vs. 11.3%; p=0.031). Multivariate analysis showed that birth season independently predicted prostate cancer.
The relationships of birth season with prostate volume and prostate cancer may be due to differences in the amount of light exposure during early pregnancy.
第二至第四指节比（指节比），这是由 决定的，与孕早期暴露于可见光和出生季节有关。指节比也与良性前列腺增生（BPH）和前列腺癌有关。这表明 BPH 和前列腺癌可能与出生季节有关。因此，本研究旨在确定前列腺体积和前列腺癌是否与出生季节有关。
共纳入 858 例下尿路症状男性患者。测量右侧指节比，并调查出生月份。测量血清前列腺特异性抗原（PSA）水平，并通过经直肠超声测量前列腺体积。怀疑患有前列腺癌的患者接受前列腺活检。
858 例患者的平均年龄、指节比、前列腺体积和血清 PSA 水平分别为 61.6 岁、0.947、36.2mL 和 4.24ng/mL。年龄、血清 PSA 水平、前列腺活检率和癌症检出率与出生季节无显著差异。然而，与夏季出生组相比，冬季出生组的指节比更低（0.951±0.040 与 0.941±0.040；p=0.014），前列腺体积更大（33.4±14.9mL 与 38.2±20.7mL；p=0.008），前列腺癌更多（5.3%与 11.3%；p=0.031）。多变量分析表明，出生季节独立预测前列腺癌。
出生季节与前列腺体积和前列腺癌的关系可能是由于孕早期光照量的差异所致。
