雄激素受体基因中CAG和GGN重复序列的长度及体细胞镶嵌现象与良性前列腺增生男性患前列腺癌的风险
Length and somatic mosaicism of CAG and GGN repeats in the androgen receptor gene and the risk of prostate cancer in men with benign prostatic hyperplasia.
作者信息
Tayeb Mohammed T, Clark Caroline, Murray Graeme I, Sharp Linda, Haites Neva E, McLeod Howard L
机构信息
Departments of Medicine, Institute of Medical Sciences, University of Aberdeen, Foresterhill, Aberdeen, UK.
出版信息
Ann Saudi Med. 2004 Jan-Feb;24(1):21-6. doi: 10.5144/0256-4947.2004.21.
BACKGROUND
The most common malignancy in men worldwide is cancer of the prostate and determinants of prostate cancer (PRCa) risk remain largely unidentified. Many candidate genes may be involved in PRCa, such as those that are central to cellular growth and differentiation in the prostate gland. We analysed the polymorphic CAG and GGN repeats sequence in exon 1 of the AR gene to determine if the number of repeats might be an indicator of PRCa risk in patients with BPH.
METHODS
The study evaluated 28 patients who presented with PRCa at least 6 years after the diagnosis of BPH and 56 matched patients with BPH who did not progress to PRCa over a comparable period.
RESULTS
This study showed no evidence for association between the size of AR CAG and GGN repeats and the risk of the development of PRCa in patients with BPH. However, BPH patients with AR CAG instability had a 12-fold increased risk in development of PRCa.
CONCLUSIONS
While independent confirmation is required in further studies, these results provide a potential tool to assist prediction strategies for this important disease.
背景
前列腺癌是全球男性中最常见的恶性肿瘤，而前列腺癌（PRCa）风险的决定因素在很大程度上仍不明确。许多候选基因可能与PRCa有关，比如那些对前列腺细胞生长和分化至关重要的基因。我们分析了雄激素受体（AR）基因外显子1中的多态性CAG和GGN重复序列，以确定重复次数是否可能是良性前列腺增生（BPH）患者PRCa风险的一个指标。
方法
该研究评估了28例在诊断为BPH至少6年后出现PRCa的患者，以及56例匹配的BPH患者，这些患者在相当长的一段时间内未发展为PRCa。
结果
本研究没有证据表明AR基因CAG和GGN重复序列的长度与BPH患者发生PRCa的风险之间存在关联。然而，AR基因CAG不稳定的BPH患者发生PRCa的风险增加了12倍。
结论
虽然需要进一步研究进行独立验证，但这些结果为辅助预测这种重要疾病的策略提供了一种潜在工具。
Zotero 插件