阑尾切除术对溃疡性结肠炎发展的保护作用：配对病例对照研究。
Protective effect of appendectomy on the development of ulcerative colitis: matched, case-control study.
作者信息
Dijkstra B, Bagshaw P F, Frizelle F A
机构信息
University Department of Surgery, Christchurch Hospital and Medical School, New Zealand.
出版信息
Dis Colon Rectum. 1999 Mar;42(3):334-6. doi: 10.1007/BF02236349.
PURPOSE
Appendectomy and cigarette smoking have been suggested to reduce the chance of developing ulcerative colitis. A case-control study was undertaken to determine the relative incidence of appendectomy in patients with ulcerative colitis.
METHODS
This case-control study examined the incidence of appendectomy in patients with ulcerative colitis and patients attending an orthopedic outpatient clinic.
RESULTS
Of 100 patients with ulcerative colitis, 75 pairs were matched for age, gender, and cigarette smoking. The ulcerative colitis group had an appendectomy rate of 8 percent (6/75), compared with 21 percent in the control group (P = 0.018). The odds ratio was 3.5 (95 percent confidence interval, 1.15-10.6).
CONCLUSIONS
No previous study has examined the effect of appendectomy, controlling for cigarette smoking. This study confirms that appendectomy protects against or reduces the chance of development of ulcerative colitis. A possible immunological explanation for this effect is advanced.
目的
有人提出阑尾切除术和吸烟可降低患溃疡性结肠炎的几率。开展了一项病例对照研究以确定溃疡性结肠炎患者阑尾切除术的相对发生率。
方法
这项病例对照研究调查了溃疡性结肠炎患者和骨科门诊患者阑尾切除术的发生率。
结果
在100例溃疡性结肠炎患者中，75对在年龄、性别和吸烟情况方面相匹配。溃疡性结肠炎组的阑尾切除率为8%（6/75），而对照组为21%（P = 0.018）。优势比为3.5（95%置信区间，1.15 - 10.6）。
结论
此前尚无研究在控制吸烟因素的情况下考察阑尾切除术的影响。本研究证实阑尾切除术可预防或降低患溃疡性结肠炎的几率。针对这一效应提出了一种可能的免疫学解释。
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