Derby L E, Jick H
Boston Collaborative Drug Surveillance Program, Boston University Medical Center, Lexington, MA 02173, USA.
Epidemiology. 1998 Mar;9(2):205-7.
We conducted a case-control study of the protective effect of appendectomy on the development of ulcerative colitis. We calculated the risk of ulcerative colitis in 716 incident cases of ulcerative colitis and 2,747 controls according to appendectomy status, using data from the United Kingdom General Practice Research Database. We also studied a random sample of 100 cases and 100 controls to validate the subject's history of appendectomy. Fifteen cases (2%) and 109 (4%) controls had a computer-recorded history of appendectomy [odds ratio (OR) = 0.5; 95% confidence interval (CI) = 0.3-0.9]. In the sample, the OR was 0.3 (95% CI = 0.1-0.9). Appendectomy appears to protect against ulcerative colitis.
我们进行了一项病例对照研究，以探讨阑尾切除术对溃疡性结肠炎发病的保护作用。我们利用来自英国全科医疗研究数据库的数据，根据阑尾切除术状态计算了716例溃疡性结肠炎新发病例和2747例对照中患溃疡性结肠炎的风险。我们还对100例病例和100例对照的随机样本进行了研究，以验证受试者的阑尾切除病史。15例病例（2%）和109例对照（4%）有计算机记录的阑尾切除病史[比值比（OR）=0.5；95%置信区间（CI）=0.3 - 0.9]。在样本中，OR为0.3（95%CI = 0.1 - 0.9）。阑尾切除术似乎对溃疡性结肠炎有预防作用。
