Binek J, Fantin A C, Meyenberger C
Division of Gastroenterology, Kantonsspital, St. Gallen.
Schweiz Med Wochenschr. 1999 Mar 20;129(11):441-5.
To assess the current attitude to Helicobacter pylori infection in Switzerland, since a review of the literature reveals few publications dealing with application of therapeutic recommendations.
The initial diagnostic methods, the indications for eradication therapy, the therapeutic regimen and its duration, together with eradication control, were indicated in questionnaires sent out to the members of the Swiss Society for Gastroenterology and Hepatology at the beginning of 1997.
Helicobacter pylori was diagnosed mainly with a rapid urease test and/or histology. Peptic ulcer disease (100%), mucosa associated lymphoid tissue (MALT) lymphoma (94.5%) and therapy-resistant dyspepsia (78.7%) were clear indications for Helicobacter pylori eradication. Only a minority eradicated Helicobacter pylori in all positive subjects. 7-day triple therapy (with proton pump inhibitors, a macrolide antibiotic and an imidazole derivative) is the preferred first line treatment.
The eradication of Helicobacter pylori in ulcer disease is established practice. Non-ulcer dyspepsia remains a controversial but often used indication. Two antibiotics together with proton pump inhibitors constitute the mostly widely used eradication therapy.
鉴于文献综述显示很少有关于治疗建议应用的出版物，评估瑞士目前对幽门螺杆菌感染的态度。
1997年初向瑞士胃肠病学和肝病学会成员发放的问卷中，列出了初始诊断方法、根除治疗的指征、治疗方案及其疗程，以及根除控制情况。
幽门螺杆菌主要通过快速尿素酶试验和/或组织学诊断。消化性溃疡病（100%）、黏膜相关淋巴组织（MALT）淋巴瘤（94.5%）和难治性消化不良（78.7%）是幽门螺杆菌根除的明确指征。只有少数人对所有阳性受试者进行了幽门螺杆菌根除。7天三联疗法（使用质子泵抑制剂、大环内酯类抗生素和咪唑衍生物）是首选的一线治疗方法。
在溃疡病中根除幽门螺杆菌已成为既定做法。非溃疡性消化不良仍然是一个有争议但经常使用的指征。两种抗生素与质子泵抑制剂一起构成了使用最广泛的根除疗法。
