Macqueen H A, Waights V, Pond C M
Department of Biology, The Open University, Milton Keynes, UK.
J Anat. 1999 Jan;194 ( Pt 1)(Pt 1):33-8. doi: 10.1046/j.1469-7580.1999.19410033.x.
We report a change in the vascularisation of the adipose depots surrounding the popliteal lymph node that has, and the contralateral node that has not, been exposed to a simulated immune challenge. The percentage of the depot that consists of vessels, as measured by image analysis, decreases over a period of 2 d after immune stimulus, then increases in a biphasic manner over the next 2-3 wk. By 1 mo after the stimulus, the vascularisation has returned to baseline values. The adipose tissue surrounding both the stimulated and the unstimulated lymph nodes shows a similar pattern, but the unstimulated depot lags by 3-6 d in reaching its maximum vascularisation. These data support the hypothesis that perinodal adipose tissue is involved in peripheral immune responses.
我们报告了腘淋巴结周围脂肪储存库血管形成的变化，其中一个储存库暴露于模拟免疫挑战，另一个对侧淋巴结未暴露。通过图像分析测量，在免疫刺激后2天内，由血管组成的储存库百分比下降，然后在接下来的2 - 3周内以双相方式增加。刺激后1个月，血管形成已恢复到基线值。受刺激和未受刺激淋巴结周围的脂肪组织显示出相似的模式，但未受刺激的储存库在达到最大血管形成方面滞后3 - 6天。这些数据支持了淋巴结周围脂肪组织参与外周免疫反应的假说。
