免疫刺激淋巴结周围脂肪库中的血管生成。
Vascularisation in adipose depots surrounding immune-stimulated lymph nodes.
作者信息
Macqueen H A, Waights V, Pond C M
机构信息
Department of Biology, The Open University, Milton Keynes, UK.
出版信息
J Anat. 1999 Jan;194 ( Pt 1)(Pt 1):33-8. doi: 10.1046/j.1469-7580.1999.19410033.x.
Abstract
We report a change in the vascularisation of the adipose depots surrounding the popliteal lymph node that has, and the contralateral node that has not, been exposed to a simulated immune challenge. The percentage of the depot that consists of vessels, as measured by image analysis, decreases over a period of 2 d after immune stimulus, then increases in a biphasic manner over the next 2-3 wk. By 1 mo after the stimulus, the vascularisation has returned to baseline values. The adipose tissue surrounding both the stimulated and the unstimulated lymph nodes shows a similar pattern, but the unstimulated depot lags by 3-6 d in reaching its maximum vascularisation. These data support the hypothesis that perinodal adipose tissue is involved in peripheral immune responses.
摘要
我们报告了腘淋巴结周围脂肪储存库血管形成的变化，其中一个储存库暴露于模拟免疫挑战，另一个对侧淋巴结未暴露。通过图像分析测量，在免疫刺激后2天内，由血管组成的储存库百分比下降，然后在接下来的2 - 3周内以双相方式增加。刺激后1个月，血管形成已恢复到基线值。受刺激和未受刺激淋巴结周围的脂肪组织显示出相似的模式，但未受刺激的储存库在达到最大血管形成方面滞后3 - 6天。这些数据支持了淋巴结周围脂肪组织参与外周免疫反应的假说。
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本文引用的文献
1
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2
A review of the microcirculation of adipose tissue: anatomic, metabolic, and angiogenic perspectives.
Microcirculation. 1997 Jun;4(2):211-32. doi: 10.3109/10739689709146786.
3
The effects of feeding suet-enriched chow on site-specific differences in the composition of triacylglycerol fatty acids in adipose tissue and its interactions in vitro with lymphoid cells.喂食富含板油的食物对脂肪组织中三酰甘油脂肪酸组成的位点特异性差异及其在体外与淋巴细胞相互作用的影响。
Br J Nutr. 1997 Apr;77(4):621-43. doi: 10.1079/bjn19970061.
4
Interactions between adipose tissue and the immune system.脂肪组织与免疫系统之间的相互作用。
Proc Nutr Soc. 1996 Mar;55(1B):111-26. doi: 10.1079/pns19960014.
5
Body fat and sympathetic nerve activity.体脂与交感神经活动。
Cardiovasc Drugs Ther. 1996 Jun;10 Suppl 1:215-22. doi: 10.1007/BF00120490.
6
Functional interpretation of the organization of mammalian adipose tissue: its relationship to the immune system.
Biochem Soc Trans. 1996 May;24(2):393-400. doi: 10.1042/bst0240393.
7
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J Lipid Res. 1995 Oct;36(10):2219-31.
8
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