Deraco M, Santoro N, Carraro O, Inglese M G, Rebuffoni G, Guadagni S, Somers D C, Vaglini M
Division of General Surgery B, Istituto Nazionale Tumori, Milan, Italy.
Tumori. 1999 Jan-Feb;85(1):1-5. doi: 10.1177/030089169908500101.
Peritoneal carcinomatosis is a common event that develops in the natural history of many neoplastic diseases, representing a major problem encountered in cancer, management. Peritoneal seedings are often associated with neoplastic ascites resulting in a source of significant discomfort to the patient. Considered in the past as a terminal condition, peritoneal carcinomatosis was approached during the last two decades as a curable disease. The introduction of cytoreductive surgery or peritonectomy in the treatment of peritoneal neoplastic diseases drastically changed the natural history of peritoneal carcinomatosis. Another technique that showed an important impact on disease control is intraperitoneal hyperthermic perfusion, one of the most fascinating treatments of peritoneal carcinomatosis that results in an impressive increase in overall survival and quality of life in treated patients with low morbidity. This review illustrates the modality of dissemination of peritoneal carcinomatosis in relation to the primary tumor site and grade of malignancy. Peritoneal carcinomatosis is a term used to define an advanced stage of many abdominal neoplastic diseases that differ in biologic aggressiveness and prognosis. The different presentation of peritoneal carcinomatosis in relation to a different primary tumor and different grade of malignancy strongly influences the potentially therapeutic radical approaches using new and advanced modalities like cytoreductive surgery and intraperitoneal hyperthermic perfusion.
腹膜癌病是许多肿瘤性疾病自然病程中常见的情况，是癌症治疗中遇到的一个主要问题。腹膜种植常伴有肿瘤性腹水，给患者带来极大不适。腹膜癌病过去被认为是终末期疾病，但在过去二十年中被视为可治愈的疾病。细胞减灭术或腹膜切除术应用于腹膜肿瘤性疾病的治疗，极大地改变了腹膜癌病的自然病程。另一种对疾病控制有重要影响的技术是腹腔热灌注化疗，这是治疗腹膜癌病最引人注目的方法之一，能使接受治疗患者的总生存率显著提高，生活质量改善，且发病率较低。本文综述了腹膜癌病相对于原发肿瘤部位和恶性程度的播散方式。腹膜癌病是一个用于定义许多腹部肿瘤性疾病晚期阶段的术语，这些疾病在生物学侵袭性和预后方面存在差异。腹膜癌病因不同的原发肿瘤和不同的恶性程度而表现各异，这强烈影响了使用细胞减灭术和腹腔热灌注化疗等新的先进方法进行潜在治疗的根治性手段。
