Arheden H, Holmqvist C, Thilen U, Hanséus K, Björkhem G, Pahlm O, Laurin S, Ståhlberg F
Department of Clinical Physiology, Lund University Hospital, Sweden.
Radiology. 1999 May;211(2):453-8. doi: 10.1148/radiology.211.2.r99ma43453.
To investigate the agreement between two noninvasive methods, magnetic resonance (MR) velocity mapping and first-pass radionuclide angiography, to quantify the pulmonary-to-systemic blood flow ratio (QP/QS) in adults, adolescents, and children with left-to-right cardiac shunts.
The accuracy and precision of MR velocity mapping were studied in 12 control subjects (six men, six women) and in a phantom. MR velocity mapping and radionuclide angiography were performed on the same day in 24 patients (16 adults, two adolescents, six children; five male patients, 19 female patients).
The mean error in QP/QS at MR velocity mapping in phantom experiments was -1% +/- 1 (mean +/- SD). In control subjects, QP/QS at MR velocity mapping was 1.03 +/- 0.03, and the cardiac index was 3.1 L/min/m2 +/- 0.2 and 3.2 L/min/m2 +/- 0.3 for women and men, respectively. In patients, QP/QS at radionuclide angiography was 14% +/- 13, higher than at MR velocity mapping. Interobserver variability was four times higher for radionuclide angiography compared with MR velocity mapping, 0% + 16 versus 0% +/- 4 (n = 12). The difference between repeated MR flow measurements in the same vessel was -1% +/- 5 (n = 36).
The data suggest that MR velocity mapping is accurate and precise for measurements of shunt size over the whole range of possible QP/QS values.
研究两种非侵入性方法，即磁共振（MR）速度成像和首次通过放射性核素血管造影术，在量化左向右分流的成人、青少年和儿童肺循环与体循环血流量比值（QP/QS）方面的一致性。
在12名对照受试者（6名男性，6名女性）和一个模型中研究了MR速度成像的准确性和精确性。在同一天对24例患者（16名成人、2名青少年、6名儿童；5例男性患者，19例女性患者）进行了MR速度成像和放射性核素血管造影术。
在模型实验中，MR速度成像测量QP/QS的平均误差为-1%±1（平均值±标准差）。在对照受试者中，MR速度成像测得的QP/QS为1.03±0.03，女性和男性的心脏指数分别为3.1 L/min/m2±0.2和3.2 L/min/m2±0.3。在患者中，放射性核素血管造影测得的QP/QS为14%±13，高于MR速度成像。与MR速度成像相比，放射性核素血管造影的观察者间变异性高4倍，分别为0%±16和0%±4（n = 12）。同一血管重复MR血流测量的差异为-1%±5（n = 36）。
数据表明，MR速度成像在整个可能的QP/QS值范围内测量分流大小是准确且精确 的。
