Lietman T, Porco T, Dawson C, Blower S
The F.I. Proctor Foundation and the Department of Ophthalmology, the University of California San Francisco, USA.
Nat Med. 1999 May;5(5):572-6. doi: 10.1038/8451.
The World Health Organization has recommended repeat mass drug administration as part of their global initiative to eliminate blinding trachoma by the year 2020. The efficacy of repeat treatment will be tested empirically, but the results will not be available for many years, and recommendations for the necessary frequency of treatment are needed immediately. We have developed a mathematical model that uses available epidemiological data from a variety of countries. We recommend, based on our analysis, that in areas where trachoma is moderately prevalent (<35% in children), it should be treated annually, but hyperendemic areas (>50% in children), it should be treated biannually.
世界卫生组织已建议进行重复群体药物给药，作为其到2020年消除致盲性沙眼全球倡议的一部分。重复治疗的效果将通过实证检验，但多年内都无法得到结果，而当下就需要针对必要治疗频率给出建议。我们开发了一个数学模型，该模型使用了来自多个国家的现有流行病学数据。基于我们的分析，我们建议，在沙眼中度流行的地区（儿童患病率<35%），应每年进行治疗；而在高度流行地区（儿童患病率>50%），应每两年进行治疗。
