Hirvonen A
Finnish Institute of Occupational Health, Helsinki.
Environ Health Perspect. 1999 Feb;107 Suppl 1(Suppl 1):37-47. doi: 10.1289/ehp.99107s137.
The variation in individual responses to exogenous agents is exceptionally wide. It is because of this large diversity of responsiveness that risk factors to environmentally induced diseases have been difficult to pinpoint, particularly at low exposure levels. Opportunities now exist for studies of host factors in cancer or other diseases in which an environmental component can be presumed. Many of the studies have shown an elevated disease proneness for individuals carrying the potential at-risk alleles of metabolic genes, but a number of controversial results have also been reported. This article is an overview of the data published to date on metabolic genotypes related to individual susceptibility to cancer.
个体对外源物质的反应差异非常大。正是由于这种反应性的巨大多样性，环境诱发疾病的风险因素一直难以确定，尤其是在低暴露水平下。现在有机会对癌症或其他可假定存在环境因素的疾病中的宿主因素进行研究。许多研究表明，携带代谢基因潜在风险等位基因的个体患疾病的倾向增加，但也有一些有争议的结果被报道。本文概述了迄今为止发表的关于与个体癌症易感性相关的代谢基因型的数据。
