Hirvonen A
Finnish Institute of Occupational Health, Helsinki, Finland.
Environ Health Perspect. 1997 Jun;105 Suppl 4(Suppl 4):755-8. doi: 10.1289/ehp.97105s4755.
The variation in individual responses to exogenous agents has been shown to be exceptionally wide. It is because of this large diversity of responsiveness that risk factors to environmentally induced diseases have been difficult to pinpoint, particularly at low exposure levels. Opportunities now exist for studies of host factors in environmentally induced cancer or other diseases in which an environmental component can be presumed. Many of the studies have shown an elevated disease proneness for individuals carrying the potential at-risk alleles of metabolic genes, but a number of controversial results have also been reported. One possible explanation for the divergent findings is lack of knowledge of the other potentially relevant genotypes for a given exposure. This paper gives an overview of the published data on combinations of metabolic genotypes in relation to individual susceptibility to environmental toxicants.
个体对外源性物质的反应差异已被证明非常大。正是由于这种广泛的反应多样性，环境诱发疾病的风险因素一直难以确定，尤其是在低暴露水平下。现在有机会对环境诱发癌症或其他可假定存在环境因素的疾病中的宿主因素进行研究。许多研究表明，携带代谢基因潜在风险等位基因的个体患疾病的倾向增加，但也有一些有争议的结果被报道。对于这些不同结果的一个可能解释是，对于给定的暴露，缺乏对其他潜在相关基因型的了解。本文概述了已发表的关于代谢基因型组合与个体对环境毒物易感性关系的数据。
