Tollbäck A, Eriksson S, Wredenberg A, Jenner G, Vargas R, Borg K, Ansved T
Department of Neurology, Karolinska Hospital, Stockholm, Sweden.
Scand J Rehabil Med. 1999 Mar;31(1):9-16.
Nine ambulatory subjects with myotonic dystrophy participated in a supervised 12-week progressive high-resistance training program. Knee extensor muscles were trained 3 times a week with free weights, 3 x 10 repetitions at 80% of 1RM. One leg was randomly chosen for training and the other served as control. Six patients completed the training program. In the trained leg, 1RM increased from 16.4 +/- 3.4 kg to 21.8 +/- 2.6 kg (p = 0.0002). There was no difference between pre- and post-training concentric or eccentric isokinetic values at 30 degrees/second in either leg. Muscle biopsy from m. vastus lateralis in the trained leg revealed no systematic difference in the degree of histopathological abnormalities before and after training. After training, there was a tendency toward increase in cross-sectional area of type I muscle fibres. However, the number of subjects was too small to draw conclusions regarding the effects of training on the histopathological changes. Magnetic resonance imaging revealed no difference in the m. quadriceps area after training. In conclusion, patients with myotonic dystrophy improved their muscle strength without any observed negative side effects after a 12-week high-resistance training program.
9名患有强直性肌营养不良的门诊患者参加了一项为期12周的有监督的渐进性高阻力训练计划。使用自由重量器械对股四头肌进行每周3次训练，以1RM的80%进行3组，每组10次重复。随机选择一条腿进行训练，另一条腿作为对照。6名患者完成了训练计划。在训练的腿部，1RM从16.4±3.4千克增加到21.8±2.6千克（p = 0.0002）。两条腿在训练前和训练后30度/秒时的向心或离心等速运动值均无差异。对训练腿部的股外侧肌进行肌肉活检显示，训练前后组织病理学异常程度无系统性差异。训练后，I型肌纤维横截面积有增加的趋势。然而，受试者数量过少，无法就训练对组织病理学变化的影响得出结论。磁共振成像显示训练后股四头肌面积无差异。总之，强直性肌营养不良患者在进行为期12周的高阻力训练计划后，肌肉力量得到改善，且未观察到任何负面副作用。
