Cervoni L, Gagliardi F M
Department of Neurosurgery, Neurological Mediterranean, Neuromed Institute IRCCS, Pozzilli, Isernia.
Minerva Ginecol. 1999 Jan-Feb;51(1-2):35-7.
Systemic metastases from ovarian carcinoma are frequent, but they rarely affect the central nervous system. The treatment of this type of metastases in not clear. Two cases of solitary cerebral metastasis from ovarian carcinoma are reported. Two patients, submitted to therapeutic protocol established for ovarian carcinoma, presented after 17 and 25 months respectively the appearance of symptoms from brain solitary metastasis without other metastases. They underwent surgery, radiotherapy and chemotherapy for solitary cerebral metastasis. Treatment of the brain lesion resulted in KPS improvement (KPS = 90) and survival was 16 and 30 months, respectively. From the 2 cases presented and the review of the literature, it appears that a better outcome may be obtained by a combined treatment of metastases, including surgery, radiotherapy and chemotherapy.
卵巢癌的全身转移很常见，但很少累及中枢神经系统。这类转移瘤的治疗尚不清楚。本文报告了2例卵巢癌孤立性脑转移病例。2例患者均遵循卵巢癌既定治疗方案，分别在17个月和25个月后出现脑孤立转移症状，无其他转移。他们接受了针对孤立性脑转移的手术、放疗和化疗。脑部病变的治疗使卡氏评分（KPS）提高（KPS = 90），生存期分别为16个月和30个月。从所呈现的2例病例及文献回顾来看，似乎联合应用手术、放疗和化疗等方法治疗转移瘤可能会取得更好的疗效。
