Sumimoto K, Tanaka I, Fukuda Y, Haruta N, Dohi K, Ito H, Tsuchiya T, Ikada Y
First Department of Surgery, Hiroshima Prefectural Hospital, Japan.
Panminerva Med. 1999 Mar;41(1):72-7.
Non-suture end-to-end anastomoses between polytetrafluoroethylene grafts and blood vessels were achieved using absorbable cuff material in experimental and clinical studies. The cuff was made of a synthetic biodegradable material, a lactic-glycolic acid copolymer, similar in composition to conventional absorbable surgical sutures.
In the experimental study, vascular anastomoses for prosthetic interposition of the infrarenal aorta in rabbits were created using the cuff method. Six months after surgery, the cuff anastomoses sites were examined angiographically and microscopically and found to be patent and smooth without neointimal hyperplasia.
The cuff layer had been completely absorbed. The clinical application used a similar technique and involved the creation of forearm bridge graft fistula in twelve patients for hemodialysis. In eight patients, Doppler fistula flow rate ranged from 167 ml/min to 392 ml/min. Ten of the twelve patients continued dialysis uneventfully. The one-year patency rate was 78% (7/9). The longest patency period was 920 days and the graft access continued to maintain sufficient blood flow for hemodialysis.
This absorbable cuff material is therefore well suited for the construction of prosthetic vascular end-to-end anastomoses.
在实验和临床研究中，使用可吸收袖套材料实现了聚四氟乙烯移植物与血管之间的非缝合端端吻合。该袖套由合成可生物降解材料制成，即乳酸-乙醇酸共聚物，其成分与传统可吸收手术缝线相似。
在实验研究中，采用袖套法为兔进行肾下腹主动脉人工血管置换的血管吻合。术后6个月，对袖套吻合部位进行血管造影和显微镜检查，发现血管通畅且光滑，无内膜增生。
袖套层已完全吸收。临床应用采用类似技术，为12例患者制作了前臂桥接移植动静脉内瘘用于血液透析。8例患者的动静脉内瘘多普勒血流量为167 ml/min至392 ml/min。12例患者中有10例继续顺利进行透析。1年通畅率为78%（7/9）。最长通畅时间为920天，移植血管通路持续保持足够的血流量用于血液透析。
因此，这种可吸收袖套材料非常适合用于构建人工血管端端吻合。
