Seabold J E, Nepola J V
Department of Radiology, University of Iowa College of Medicine, Iowa City, USA.
Q J Nucl Med. 1999 Mar;43(1):21-8.
Labeled leukocyte scintigraphy is the preferred imaging technique for the evaluation of suspected postoperative orthopedic infections. Labeled leukocyte localization returns to a normal pattern faster than MRI after bone trauma, surgical procedures, and treatment of osteomyelitis. 99mTc HMPAO labeled leukocyte scintigraphy is useful, particularly in children, because less peripheral blood volume is required for labeling. However, delayed 16-20 hour imaging is usually needed to detect low-grade osteomyelitis, and 111In WBC usually provides better images in adults. Combined 111In WBC/99mTc sulfur colloid marrow images improve the specificity for detection of osteomyelitis in regions containing active bone marrow. Simultaneous 111In leukocyte/99mTc bone SPECT imaging is usually necessary in regions such as the skull, spine, and hips, where there is overlapping bone, and soft tissues.
标记白细胞闪烁扫描术是评估疑似骨科术后感染的首选成像技术。在骨创伤、外科手术及骨髓炎治疗后，标记白细胞定位恢复至正常模式的速度比MRI更快。99mTc HMPAO标记白细胞闪烁扫描术很有用，尤其对于儿童，因为标记所需的外周血量较少。然而，通常需要延迟16 - 20小时成像以检测轻度骨髓炎，而111In WBC通常能为成人提供更好的图像。联合111In WBC/99mTc硫胶体骨髓图像可提高在含有活跃骨髓区域检测骨髓炎的特异性。在颅骨、脊柱和髋部等存在骨骼和软组织重叠的区域，通常需要同时进行111In白细胞/99mTc骨SPECT成像。
